Experimental Evaluation of some central nervous system Activities of Calcium Channel Blockers: Effect on isolation Combativeness and Suppression of Conditioned Avoidance Response.


Chitra Singh, Madhu Singh




The present study was designed to investigate effect of some Calcium Channel Blockers on Central Nervous System activities in terms of Isolation Combativeness and Suppression of Conditioned Avoidance Response. This present study was carried out over three different classes of CCB’s, namely Benzothiazipine, Dihydropyridine and Piperazine, to evaluate their control activities on Central Nervous System. For this purpose Diazepam served as control. All the above tests were carried out over Albino Rats. In case of isolation combativeness Diltiazem in all three doses viz.; 5mg/kg,10mg/kg,20mg/kg and Flunarizine and Nifedipine in a dose of 20mg/kg,10mg/kg respectively effectively calm down the animals. During screening of conditioned avoidance response; Diltiazem was effective in all the three doses viz. 5mg/kg, 10mg/kg, 20mg/kg. While Flunarizine and Nifedipine, were partly effective. Calcium channel blockers: Diltiazem, Flunarizine, Nifedipine in different doses: can affect central nervous system functions in different ways and can interact with some other drugs effective on central nervous system.




CCBs; isolation combativeness; conditioned avoidance response; diltiazem; nifedipine; Flunarizine; diazepam; aggressiveness; learning; memory


Full Text:


DOI: http://dx.doi.org/10.7439/ijpr.v3i3.52

Article Metrics

Metrics Loading …

Metrics powered by PLOS ALM


  • There are currently no refbacks.


Copyright (c) 2014 International Journal of Pharmacological Research

Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.

Dr. Jun Ren is a dedicated and experienced registered dietitian and nutritionist who is committed to helping people achieve their health goals through personalized nutrition plans. With a passion for promoting healthy eating habits and preventing chronic diseases, Dr. Ren has been able to assist numerous clients in improving their overall quality of life.

Leave a Comment