Quantitative estimation of Donepenzil hydrochloride tablet by HPLC



  • Sadath Ali

    Glocal School of Pharmacy,
    Glocal University, Saharanpur, U.P

  • Mohamad Taleuzzaman

    Glocal University, Saharanpur.U.P.

  • Sadaf Jamal Gilani

    Glocal School of Pharmacy,
    Glocal University, Saharanpur, U.P

  • Md Liyakat Ahmed

    Department of Biotechnology,
    Acharyanagarjuna University, Guntur, A.P

  • Abdul Hafeez

    Glocal School of Pharmacy,
    Glocal University, Saharanpur, U.P




A simple, rapid, reliable and accurate HPLC method has been developed and validated as per the ICH guidelines for the quantitative determination of Donepezil HCl in bulk and tablets. The water HLC-10, high performance liquid chromatography system were used. The LOQ is detected at concentration 0.05mg/ml and the linearity range is 50-150g/ml. An optimum concentration scanned in the range 200-350 nm and ? max of the drug is 230 nm. No any interference at developed (R t = 8.22 min) and also the ? max peak is sharp. The Accuracy of the method was found to be in the range of 99.70% to 100.26%. The mean Inter and Intraday assay Relative Standard deviation (%RSD) were less than 0.69%. The Proposed method was found to be Linear, precise and accurate for the quantitative estimation of Donepezil in tablet formulations and can be used for commercial purposes.


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How to Cite

Ali S, Taleuzzaman M, Gilani SJ, Ahmed ML, Hafeez A. . Int J of Pharm Chem [Internet]. 2016Feb.29 [cited 2020May31];6(2):62-6. Available from: https://wordpress-973677-4103585.cloudwaysapps.com/index.php/ijpc/article/view/3022


Vol. 6 No. 2 (2016): Feb


Research Articles

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