Recurrent Pregnancy Loss (RPL), ReciprocalTranslocation, Robertsonian Translocation.
Background: Recurrent Pregnancy Loss (RPL) is an important reproductive health problem. The present study was carried out to find out the frequency and types of chromosomal anomalies in couples who consulted the Department of Obstetrics and Gynaecology, seeking treatment for RPL. They were examined and investigated at the Institute of Maternal and Child Health, Government Medical College, Kozhikode, which is a Tertiary care Centre of North Kerala.
Study Settings and Design: A retrospective study of karyotypes of 125 couples was done. The results of cytogenetic analysis over a period of 7 years were assessed.
Method: Peripheral blood lymphocytes were cultured according to standard protocol and karyotypes were analysed using Cytovision Software Version 7 and expertise of staff.
Results: Out of 125 couples, 114 (91.2%) couples had apparently normal karyotypes. Remaining 11 couples (8.8%) showed chromosomal anomalies.
Conclusion: This study shows the importance of karyotyping in couples with recurrent pregnancy loss. Early diagnosis and genetic counseling can be offered to affected couples.
Alijotas-Reig J, Garrido-Gimenez C. Current concepts and new trends in the diagnosis and management of recurrent miscarriage. ObstetGynecolSurv2013;68: 445–66.
Sugiura-Ogasawara M, Ozaki Y, Katano K, Suzumori N, Kitaori T, Mizutani E.) Abnormal embryonic karyotype is the most frequent cause of recurrent miscarriage. Hum Reprod. 2012;27(8): 2297–303.
De Braekeleer M, Dao TN. Cytogenetic studies in couples experiencing repeated pregnancy losses. Hum Reprod. 1990;5(5): 519–28.
Rao l,Murthy K,Babu A et al. Chromosome inversions and a novel chromosome inversion associated with recurrent miscarriage in South India,Arch GynecolObstet.2005:272:273-7.
Practice Committee of the American Society for Reproductive Medicine Evaluation and treatment of recurrent pregnancy loss: a committee opinion. FertilSteril. 2012;98(5): 1103–11.
Pal S, Ma SO, Norhasimah M, Suhaida MA, Siti Mariam I, Ankathil R, et al. Chromosomal abnormalities and reproductive outcome in Malaysian couples with miscarriages. Singapore Med J. 2009;50:1008–12
Sudhir N, Kaur T, Beri A, Kaur A. Cytogenetic analysis in couples with recurrent miscarriages: A retrospective study from Punjab, North India. J Genet. 2016;95:887–94.
Ghazaey S, Keify F, Mirzaei F, Maleki M, Tootian S, Ahadian M, et al. Chromosomal analysis of couples with repeated spontaneous abortions in Northeastern Iran. Int J FertilSteril. 2015;9:47–54.
Gonçalves RO, Santos WV, Sarno M, Cerqueira BA, Gonçalves MS, Costa OL. Chromosomal abnormalities in couples with recurrent first trimester abortions. Rev Bras Ginecol Obstet. 2014;36:113–7.
Flynn H, Yan J, Saravelos SH, Li TC. Comparison of reproductive outcome, including the pattern of loss, between couples with chromosomal abnormalities and those with unexplained repeated miscarriages. J ObstetGynaecol Res. 2014;40:109–16.
Sheth FJ, Liehr T, Kumari P, Akinde R, Sheth HJ, Sheth JJ. Chromosomal abnormalities in couples with repeated fetal loss: An Indian retrospective study. Indian J Hum Genet. 2013;19:415–22.
Dutta UR, Rajitha P, Pidugu VK, Dalal AB. Cytogenetic abnormalities in 1162 couples with recurrent miscarriages in Southern region of India: Report and review. J Assist Reprod Genet. 2011;28:145–9.
Goud TM, Mohammed Al Harassi S, Khalfan Al Salmani K, Mohammed Al Busaidy S, Rajab A. Cytogenetic studies in couples with recurrent miscarriage in the Sultanate of Oman. Reprod Biomed Online. 2009;18:424–29.
Nazmy NA. Cytogenetic studies of couples with reproductive failure in Alexandria, Egypt. J Egypt Public Health Assoc. 2008;83:255–71.
Chromosomal analyses of 1510 couples who have experienced recurrent spontaneous abortionsErdalTunç 1, NilgünTanrıverdi 1, Osman Demirhan 2, DilaraSüleymanova 1, NesrinÇetinel 1Reprod Biomed Online. 2016 Apr;32(4):414-9.
Malik Ejder, YildirimSavasKarakus, HandeKucuk, KurtulganBurakBaser.The type and prevalence of chromosomal abnormalities in couples with recurrent first trimester abortions: A Turkish retrospective study. Journal of Gynecology Obstetrics and Human Reproduction. Sept. 2019; 48(7): 521-25
WiemAyed,IslemMessaoudi, ZouhourBelghith, et al. Chromosomal abnormalities in 163 Tunisian couples with recurrent miscarriages. Pan Afr Med J. 2017; 28: 99.
ZouhairElkarhat , ZinebKindil , LatifaZarouf et al. Chromosomal abnormalities in couples with recurrent spontaneous miscarriage: a 21-year retrospective study, a report of a novel insertion and a literature review.J Assist ReprodGenet2019 Mar;36(3):499-507. E Pub 2018 Nov 23.
Hady El Hachem, Vincent Crepaux et al. Recurrent Pregnancy loss: Current perspectives. International journal of Women’s health,2017;9: 331-45,
Werner M, Reh A, Grifo J, Perle MA. Characteristics of chromosomal abnormalities diagnosed after spontaneous abortions in an infertile population. J Assist Reprod Genet. 2012;29:817–20.
Purandare H, Fernandez NV, Deshmukh SV, Chavan S. Heterochromatic variations and pregnancy losses in humans. Int J Hum Genet. 2011;11:167–75.
Minocherhomji S, Athalye AS, Madon PF, Kulkarni D, Uttamchandani SA, Parikh FR, et al. Acase-control study identifying chromosomal polymorphic variations as forms of epigenetic alterations associated with the infertility phenotype. FertilSteril. 2009;92:88–95.
Van Dijk MM, Kolte AM, Limpens J, et al. Recurrent pregnancy loss: diagnostic workup after two or three pregnancy losses? A systematic review of the literature and meta-analysis. Hum Reprod Update 2020; 26:356–367.
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