Comparative evaluation of urine isolates among kidney transplanted and other UTI suspected patients visiting National Public Health Laboratory, (NPHL) Teku, Nepal


Goma Upadhyay, Prakash Ghimire, Geeta Shakya, Bishnu Prasad Upadhyaya, Sony Shrestha, Shamshul Ansari




Objective: This study compare the prevalence of urinary tract infection among kidney transplanted and other UTI suspected patients visiting National Public Health Laboratory, Teku, Nepal. Materials and Methods: The study was carried out from January 2011 to October 2011. During this period, a total of 1233 urine samples from patients suspected of UTI were collected and processed. The antimicrobial susceptibility was tested by the modified Kirby-Bauer’s disc diffusion method as per the CLSI guidelines. All the data obtained was statistically analyzed by using Statistical Package for Social Sciences (SPSS) version 16. Results: Prevalence of uropathogens was found to be 14.19% (175/1233). 16 species of different bacterial isolates were isolated, identified and among them, 94.29% (165/175) were of Gram negative and 5.71% (10/175) of Gram positive organisms. Out of total 439 Kidney transplanted patients, only 5.01% (22) of urine sample showed significant growth. The most efficient first line antibiotic for isolates was found to be Ceftriaxone 68.57%, and in second line antibiotics Ceftazidime-clavunic acid and Amikacin showed better efficacy. In the total 175 uropathogens, 48% (84/175) isolates were found to be MDR isolates. Conclusion: A 14.19% prevalence of UTIs was found. 94.29% (165/175) of Gram negative uropathogens were found to be predominant. This study showed the significant association between infection among Kidney transplanted and Nontransplanted patients (p<0.05).




Urinary Tract Infection; Kidney transplant; MDR


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